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KMID : 0043319950180060415
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Archives of Pharmacal Research
1995 Volume.18 No. 6 p.415 ~ p.422
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Antimutagenic Activities of 24 Synthetic Flavones with The Salmonella Microsomal Assay
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Laget M.
Meo M. De
J.C.Wallet
E.M.Gaydou
H.Guiraud
G.Dumenil
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Abstract
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Twenty-four flavones were synthesized with various hydroxyl and/or methoxyl groups on A and B rings. Their antimutagenic properties were evaluated against ben:w(a)pyrene (BaP) and a pool of mutagenic urine concentrate (U) using a modified liquid incubation method of Ames test. The tester strain was Salmonella typhimurium TA98+S9 Mix. The antimutagenic activities were calculated by non linear regression analysis and the doses of flavones (in nmoles) required for a 50% reduction of induced revertants with BaP and U were defined as the inhibition doses (TEX>$ID_{508}{\;}and{\;}ID_{508}$ respectively). Seventeen flavones possessed significant antimutagenic activity against BaP. ranged from 15.1 nmoles (F22) to 1000.6 nmoles (F13). Eighteen f1avones showed significant antimutagenic activity against U. ranged from 23.5 nmoles (F22) to 354.6 nmoles (F3). The 2’,3’,4’-trihydroxyflavone (F22, nmoles, nmoles) and the 2’,3’,4’,7-tetrahydroxyflavone (F20, nmoles; nmoles) had antimutagenic activities similar to those of chlorophyllin ( nmoles and nmoles) and were evaluated against B(alP 7,8-dihydrodiol-9,10-epoxide. Against this last mutagen, the flavones which included three OH in B ring showed the highest activity and this property seemed independent of the substituent groups on A ring.
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KEYWORD
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Antimutagens, Methoxyflavones, Hydroxflavones, Ames test
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